Effect of neuraminidase on potency of inactivated influenza virus vaccines in mice.
Identifieur interne : 002B64 ( Main/Exploration ); précédent : 002B63; suivant : 002B65Effect of neuraminidase on potency of inactivated influenza virus vaccines in mice.
Auteurs : E. Reichert ; R. MaulerSource :
- Developments in biological standardization [ 0301-5149 ] ; 1975.
Descripteurs français
- KwdFr :
- Animaux, Infections à Orthomyxoviridae (immunologie), Orthomyxoviridae (enzymologie), Polysorbates (pharmacologie), Production d'anticorps, Sialidase (administration et posologie), Sialidase (immunologie), Sialidase (pharmacologie), Souris, Vaccination, Vaccins antigrippaux (), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (normes).
- MESH :
- administration et posologie : Sialidase, Vaccins antigrippaux.
- enzymologie : Orthomyxoviridae.
- immunologie : Infections à Orthomyxoviridae, Sialidase.
- normes : Vaccins antigrippaux.
- pharmacologie : Polysorbates, Sialidase.
- Animaux, Production d'anticorps, Souris, Vaccination, Vaccins antigrippaux.
English descriptors
- KwdEn :
- Animals, Antibody Formation, Influenza Vaccines (administration & dosage), Influenza Vaccines (classification), Influenza Vaccines (standards), Mice, Neuraminidase (administration & dosage), Neuraminidase (immunology), Neuraminidase (pharmacology), Orthomyxoviridae (enzymology), Orthomyxoviridae Infections (immunology), Polysorbates (pharmacology), Vaccination.
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Neuraminidase.
- chemical , classification : Influenza Vaccines.
- chemical , immunology : Neuraminidase.
- chemical , pharmacology : Neuraminidase, Polysorbates.
- chemical , standards : Influenza Vaccines.
- enzymology : Orthomyxoviridae.
- immunology : Orthomyxoviridae Infections.
- Animals, Antibody Formation, Mice, Vaccination.
Abstract
The protective effect of neuraminidase was studied in a mouse protection test using isolated neuraminidase of A2/Aichi/68(H3N2) virus and the complete recombinant virus A/eq(Heq-1)-HK(N2) as antigens. Immunized mice were protected against A2/Aichi(H3N2) challenge virus; however, the protection rate was low in comparison to animals immunized with comparable amounts of the complete A2/68(H3N2) virus9 Furthermore there was no cross-protection against A2/Asia/57(H2N2) challenge virus. The protective effect of neuraminidase was not impaired by Tween-ether treatment of the A/eq(Heq-1)-HK(N2) recombinant virus.
PubMed: 1126575
Affiliations:
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Le document en format XML
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Reichert</name></author><author><name sortKey="Mauler, R" sort="Mauler, R" uniqKey="Mauler R" first="R" last="Mauler">R. 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Immunized mice were protected against A2/Aichi(H3N2) challenge virus; however, the protection rate was low in comparison to animals immunized with comparable amounts of the complete A2/68(H3N2) virus9 Furthermore there was no cross-protection against A2/Asia/57(H2N2) challenge virus. The protective effect of neuraminidase was not impaired by Tween-ether treatment of the A/eq(Heq-1)-HK(N2) recombinant virus.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Mauler, R" sort="Mauler, R" uniqKey="Mauler R" first="R" last="Mauler">R. Mauler</name><name sortKey="Reichert, E" sort="Reichert, E" uniqKey="Reichert E" first="E" last="Reichert">E. Reichert</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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